Dr. Hongliang Li is a full professor of Medicine at Wuhan University. He currently serves as the Directors of Animal Research Center of Wuhan University, Collaborative Innovation Center of Model Animal, and Acting Director of Cardiovascular Research Institute of Wuhan University. After obtaining his Ph.D. degree from the Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Dr. Li pursued his post-doctoral trainings in Joslin Diabetes Center of Harvard Medical School and Department of Cardiology at the University of Toronto. He was selected as an awardee for Distinguished Young Scholars of National Nature Science Foundation Committee of China in 2014. In the past 15 years, he has published over 100 peer reviewed papers in high impact factor journals including Nature Communications, Circulation, Circulation Research, Hepatology, Journal of Hepatology, PNAS, Diabetes, Cell Death Differentions, Hypertension, and Cardiovascular Research. Since 2008, he has been funded for more than $ 20 million from Ministry of Science and Technology, Ministry of Education, and National Natural Science Foundation Committee of China. Currently, Dr. Li’s research interest focuses on defining the novel roles of innate immune network in cardiometabolic diseases. He is also interested in the development of biotechnology for genome manipulation and animal model of human diseases.
Dr. Zan Huang is a full Professor of College of Life Sciences, Wuhan University. He graduated from Molecular Biology Program of Loyola University Chicago with a Ph.D. degree and continued his postdoctoral training in Chicago University and Northwestern University from 2006 to 2010. Dr. Huang has published more than 40 peer-reviewed papers on high impact factor journals including Journal of Clinic Investigation, Blood, Leukemia, CMLS, JBC, Journal of Immunology. He was selected as an awardee for Program for New Century Excellent Talents in University (NCET) of Ministry of Education of China and Chutian Scholar of Hubei Province. He is currently a member of American Society of Hematology. Dr. Huang’s research interest focuses on molecular mechanisms in leukemogenesis, hematopoiesis, and hepatic steatosis.
Sijun Yang., Ph.D., Associate Professor
Ke Zhuang, M.D., Ph.D., Lecturer
Dr. Ke Zhuang is a lecturer of the Center for Animal Experiment and ABSL-3 Laboratory at Wuhan University. Dr. Zhuang obtained her M.D. and Ph.D. degrees from Wuhan University School of Medicine in 2002 and 2005. She worked in College of Life Sciences at Wuhan University during 2005-2008 and pursued her post-doctoral trainings in Aaron Diamond AIDS Research Center of Rockefeller University in New York from 2008 to 2012. Dr. Zhuang has been doing HIV/AIDS research for more than 10 years. Dr. Zhuang is currently interested in non-alcoholic steatohepatitis（NASH）and pathogenesis of HIV-Associated B- cell Lymphoma.
Dr. Li ZHOU, Ph.D., Instructor of Medicine
Dr. Li Zhou is an instructor of medicine in Center for Animal Experiment, Wuhan University. He graduated from College of Life Sciences, Wuhan University with Ph.D. degree in 2011 and continued his postdoctoral training in Wuhan University School of Medicine from 2012 to 2014. Dr. Zhou’s research interest focuses on molecular mechanisms in acute lung disease and innate immunity.
Jianfeng Gao,Ph.D., Lecturer
Dr. Jianfeng Gao is a lecturer of the Center for Animal Experiment at Wuhan University. Dr. Gao graduated from Huazhong Agricultural University with a doctoral degree in June, 2014 and then pursued his post-doctoral trainings at Wuhan University School of Medicine from 2014 to 2016. Dr. Gao’s research interest focuses on molecular mechanism of nutritional metabolic disease.
The research supporting team is mainly responsible for managing multiple technical platforms for research and service including Gene Modification Platform, Micromanipulation Platform, Animal Model Platform, Animal Management Platform, Pathology Analysis Platform, Cell Biology Platform, Informatization Platform, High-throughput Screening and Analysis Platform, and Molecular Detection Platform. These platforms aim to provide comprehensive, professional, and efficient technical support for investigators from universities, institutes, and hospitals majoring in the biomedical research.
Gene Modification Platform creates new experimental animals and cell models by using transgenic technology, gene knockout/knock-in technology, viral transduction etc. to introduce, delete, or modify particular host gene.
Micromanipulation Platform provides genetically modified animals and related technical services such as sperm freezing, embryo freezing, in vitro fertilization，strain depuration etc by microinjection and embryo transfer technologies.
Animal Model Platform provides various animal models to reproduce similar pathological damages (function, metabolism, or morphology) to that in human diseases by artificially introducing pathogenic stimulus (physical, chemical, or biological interventions). These models may be valuable for study the etiology, prevention, and therapeutics of human diseases
Rui Zhang, technician, more than 5 years research experience of animal experiment. He is skilled in rat and mice myocardial infarction model, cardiac ischemia/reperfusion injury, and ultrasonic inspection and measurement for rat and mice.
Xi Wang, technician, with more than 5 years research experience of animal experiment. She is mainly skilled in tumor models, such as intestinal cancer, gastric cancer, liver cancer, lung cancer, and carcinoma of urinary bladder
Xiangjie Kong, technician, skilled in rat and mice cardiac hypertrophy models
Qiang Wang, technician, skilled in rat and mice cardiac hypertrophy models, and hemodynamic measurement for rat and mice
Qiaofang Wei, technician, mainly responsible for establishing diabetes model, atherosclerosis model, abdominal aneurysm model, and non-alcoholic fatty liver disease model.
Cheng Du, technician, mainly responsible for establishing diabetes model, atherosclerosis model, abdominal aneurysm model, and non-alcoholic fatty liver disease model.
Shuo Xiong, technician, mainly responsible for establishing diabetes model, atherosclerosis model, abdominal aneurysm model, and non-alcoholic fatty liver disease model.
Xiangyu Zhu, technician, skilled in establishing mice liver and kidney ischemia/reperfusion injury models.
Animal Management Platform aims to normalize and standardize the animal feeding based on the SPF conditions and provides the services for laboratory rodents such as strain depuration, live conservation, frozen conservation, strain breeding and expanding. Our platform has 600 strains of genetic engineer mice, and 100 strains of genetic engineer rats.
Pathology Analysis Platform aims to examine the pathological changes occurring in different organs, tissues, or cell types. Major tasks include tissue processing (fixation, dehydration, embedding, and tissue section), staining (H&E, Immunofluorescence, and Immunohistochemistry), and observation.
Cell Biology Platform is to provide primary cells and cell lines for research, perform compound screen at cell level, and establish cell bank.
Ling Huang, director of Cell Biology Platform, master degree in biomedical engineering from Renmin Hospital of Wuhan University, more than 3 years of research experience in cell culture. She is mainly responsible for primary cell culture, cell model establishing, and establishing cell bank.
Yusang Su, technician of Cell Biology Platform, master degree IN biomedical engineering from Huazhong Agricultural University. She is mainly responsible for cell culture, cell model, and cell bank establishing
Informatization Platform is responsible for informatizing management of genetic animals resources, animal model resources, plasmid resources, virus resources, cell resources, research data and, personnel archives and establishing related libraries to integrate various resources and insure the integrity and accuracy of research data.
Li Zhang, master degree from Huazhong Agricultural University. She is mainly responsible for patent application and data arrangement of genetic animals.
High Throughput Screening Platform aims to identify genes, proteins and metabolites relevant to human diseases by using high throughput technologies including microarray, RNA-seq, protomics, and metabonomics. Thus we try to systemically elucidate possible mechanisms underlying the pathogenesis of human diseases at gene expression, protein expression, and metabolite levels, which will provide powerful clue and idea for our research group. This platform also aims to mine high throughput data of the lab and public available database to search the novel target molecules relevant to human diseases and provide inexhaustible stimulus for our research group.
Molecular Detection Platform is responsible for quantitative analysis of protein and mRNA expression.
Guangnian Zhao, Ph.D.
Guangnian Zhao graduated from Peking Union Medical College and Chinese Academy of Medical Sciences with a Ph.D. degree in 2013.
Peng Zhang, Ph.D.
Peng Zhang is a postdoctoral student in the laboratory. He recently obtained his Ph.D. from Shanghai Jiaotong University in 2014.
Junhong Guo, Ph.D.
Junhong Guo is a postdoctoral student in the laboratory. She has recently obtained her Ph.D. from Wuhan University in 2014.
Yanxiao Ji, Ph.D.
Yanxiao Ji is a postdoctoral student in the laboratory. He has recently graduated from Wuhan University with a Ph.D. in 2015.
Yaxing Zhang, Ph.D.
Yaxing Zhang recently graduated with a Ph.D. from Sun Yat-sen University.
Chun Fang, Ph.D.
Chun got his doctoral degree from the Institute of Preventive Veterinary Medicine of Zhejiang University in 2015.
Wenzhe Mao, Ph.D.
Mao Wenzhe graduated with Ph.D. from Chinese Academy of Medical Sciences &Peking Union Medical College.
Xi Jiang is currently a Ph.D. candidate in Cardiology Department of the Renmin Hospital of Wuhan University.
Pixiao Wang is currently a Ph.D. candidate in Cardiology Department of the Renmin Hospital of Wuhan University.
Jun Gong, B.Sc.
Jun Gong is now a Ph.D. candidate in College of Life Sciences at the Wuhan University.
Wenlin cheng is currently a Ph.D. student in Cardiology Department of Renmin Hospital of Wuhan University.
Xiaozhan Wang is currently a Ph.D. in Cardiology Department of Renmin Hospital of Wuhan University.
Zhou Jiang, B.Sc.
Zhou Jiang is a Ph.D. student in College of Life Science at Wuhan University.
Fengjuan Yan, B.Sc.
Fengjuan Yan is a Ph.D. student in the College of Life Sciences of Wuhan University.
Yi Ren is a Ph.D. student in College of Life Science of Wuhan University.
Min Wang, B.Sc.
Min Wang is a graduate student in College of Life Sciences at Wuhan University.
Wanlin Qiu, B.Sc.
Wanlin Qiu is a graduate student in the College of Life Sciences at Wuhan University.
Keqiong Deng is currently a Master candidate in Cardiology Department of Renmin Hospital of Wuhan University.
Lijun Shen is currently a Master student in Cardiology Department of Renmin Hospital of Wuhan University.
Lingping Zhao is now a Master student in Cardiology Department of Medical Research Institute at Wuhan University.
Zhenzhen Yan, B.Sc.
Zhenzhen Yan is a graduate student in College of Life Sciences at Wuhan University.
Cuijuan Han, B.Sc.
Cuijuan Han is a graduate student in College of Life Sciences at Wuhan University.
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